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ID : tm2929810269


Preventive effect of ethanolic extract of Phyllanthus niruri on thioacetamide-induced liver cirrhosis in rats

After 60 days treatment, all animals were sacrified. Grossly, TAA plus distilled water-treated group resulted in a uniform coarse granulation of the surface of the rat's liver, thus the surface of liver was rough and formation of small nodules observed, indicating that live fibrosis developed as expected. Compared to TAA plus plant extract treated group, a uniform coarse granulation was comparatively milder on the surface of rat's liver.

Kuala Lumpur Kuala Lumpur

ID : tm2930610277


PlasmoNex II : A PCR System For Detection Of General And Human Malaria Parasites

Human malaria is commonly resulted by the infection with one or mixed of the four species of Plasmodium parasites, i.e., P. vivax, P. falciparum, P. malariae, and P. ovale. However, for the past 7 years, cases of P. knowlesi (simian Plasmodium) infection were also reported in human.

In general, microscopy examination of Glemsa-stained thin and/or thick blood films is always been used as the gold standard for routine laboratory diagnosis of malaria. This inexpensive and rapid assay enables identification of plasmodium species and quantification of parasites. However, the approach sensitivity drops with the decrease of parasitemia as well as in cases of mixed infection.

Therefore, we have developed a sensitive, specific, cost-effective single step PCR method for the detection of general malaria parasites including the five main human malaria parasites, P. falciparum, P. vivax, P. malariae, P. ovale, and P. knowlesi. Overall, this approach is developed using bioinformatics tools and tested on the bench using various plasmodium dipstick kits in the market and it is easy to carry out and not so time-consuming and laborious compared to plasmodium detection using nested PCR approach.

Kuala Lumpur Kuala Lumpur

ID : tm2930710278


Plasmonex ??? A Single Step Multiplex Pcr Detection System for Human Malaria Parasites

This is a single step PCR method for the detection of five main human malaria parasites, P. falciparum, P. vivax, P. malariae, P. ovale, and P. knowlesi with a stable internal control.

Kuala Lumpur Kuala Lumpur

ID : tm2930810279


Plasmonex - Advanced Detection System For Malaria Parasites

Human malaria is commonly resulted by the infection with one or mixed of the four species of Plasmodium parasites, i.e., P. vivax,Palciparum, P.malariae, and P.ovale. However, for the past 7 years, cases of P.knowlesi (simian Plasmodium) infection were also reported in human. In general, microscopy examination of Giemsa-stained thin and/or thick blood films is always been use as the gold standard for routine laboratory diagnosis of malaria. This inexpensive and rapid assay enables identification of plasmodium species and quantification of parasites.

However, the approach sensitively drops with the decrease of parasitemia as well as in cases of mixed infection. Therefore, we have made an attempt to develop a sensitive, specific, cost-effective single step multiplex PCR method for the detection of five main human malaria parasites, P.falciparum, P.vivax, P.malariae, P.ovale, and P.knowlesi.

Kuala Lumpur Kuala Lumpur

ID : tm2930910280


Plasma Expander-Characterization and Formulation of Gelatin Chicken Leg

Gelatin is the main protein-derivative of a mild but irreversible collagenolytic breakdown from collagen containing tissue of porcine, bovine, fish, poultry or seaweed origin. Poultry by-products are not often processed to high value products. Plasma expanders are used in:- i) management of hypovolaemia or burn cases ii) maintenance of adequate circulation of blood volume

Kuala Lumpur Kuala Lumpur

ID : tm2931210283


Patient Self Management for Woman with Breast Cancer: Enhancing participation and QOL.

Patient self management is an essential part of medical care for chronic disease. Its application with oncology conditions is relatively new. Cancer, particularly breast cancer, has become a form of chronic illness which requires a new model of care. This book provides evidence on patient self management for breast cancer, and is useful as a guide for health professionals or researchers who are considering utilizing the framework for complex intervention to assess innovative program.

Kuala Lumpur Kuala Lumpur

ID : tm2931810289


Osteoknee

Osteoknee is a new assistive medical device which can perform early detection and prevention of osteoarthritis (OA). Osteoknee is a non-invasive, radiation-free,portable and standalone point-of-care device.The diagnosis procedure will be relatively inexpensive compare to existing technologies.

Kuala Lumpur Kuala Lumpur

ID : tm2932410295


One-Step SYBR Green I Based Real Time RT-PCR Assay ofr Detection and Quantification of the Chikungunya and Dengue Virus

Dengue and Chikungunya are two arboviral infections of importance in Malaysia that circulate simultaneously. Both are transmitted by hte Aedes sp, cause similar infections such as sudden onset fever, headache, rashes and myalgia, with neither having any specific treatmer or tetravalent vavvine. Therefore good management of patients is needed in trying to reduce both morbidity and mortality rates and this is dependent on accurate and early diagnosis of both infections. Giagnosis currently depents on conducting indidual lgM ELISA for each infection and also singleplex RT-PCR.Confirmation however still requires isolation of the virus and this takes more than a week.

Kuala Lumpur Kuala Lumpur

ID : tm2932510296


One-Step DEN-CHIK Multiplex Real-Time QRT-PCR Kit

Dengue and Chikungunya are two arboviral infections of importance in Malaysia which simultaneously.Both are transmitted by the Aedes sp,cause similar infections with neither having any specific treatment or vaccine. Therefore,good management of patients is needed to reduce both morbidity and mortality rates and this is dependent on accurate and early diagnosis of both infections.Current diagnosis depends on conducting individual IgM ELISA for each infection,and confirmation however still requires isolation of the virus and this takes more than a week.Hence having a diagnostic test to dtect and differentiate the two infections simultaneously would certainly be benificial.One-step Den-Chik multiplex real-time RT-PCR kit allow simultaneous detection and qualification of denque and chikungunya virus in biological samples.This assay is based on SYBR green I real -time RT-PCR uses in-house designed forward and reverse primers.The assay is rapid,sensitive and specific as a diagnostic tool for the diagnosis of dengue and chikungunya infections in a clinical laboratory setting.

Kuala Lumpur Kuala Lumpur

ID : tm2932610297


One Step DEN AG-AB Kit

One step dengue antigen antibody kit is an assay that is able to diagnose a dengue infection irrespective of the day of onset.The aim of the assay is simultaneously detection of multiple targets including antigens and antibodies present in the sample in a single step.The existing tests have limitation of detecting only a single analyte at a time and may result in delay in diagnosis if the target was not detected.Hence detecting both the infecting viral antigen and antibodies in a single reaction will greatly improve the diagnosis of dengue.The assay is based on the bead array platform whereby beads coupled individually with a variety of reagents including anti-dengue NS1 antigen and anti-human IgM/IgG. Viral antigen or antibodirs will bind to the beads if there is a positive reaction.This assay is rapid, sensitive and specific diagnostic tool for dengue in a clinical laboratory setting,and thus useful for management of patients.

Kuala Lumpur Kuala Lumpur

ID : tm2933010301


Novel Polymeric Gemcitabine Derivative for Cancer Treatment: Poly-L-Glutamic Acid-Gemcitabine

This invention relates to :
? A novel polymeric gemcitabine derivative for cancer treatment
? Conjugation of gemcitabine (G) to a water-soluble polymer, poly-L-glutamic acid (PG) to yield a novel gemcitabine derivative i.e poly-Llglutamic acid-gemcitabine (PG-G: GD200401)
? Provide self targetting antitumour polymeric gemcitabine derivative to breast cancer, solid tumours and other fprms of tumours.
? Stable in normal storage conditions and has low acute toxicity

Kuala Lumpur Kuala Lumpur

ID : tm2933210303


New Saliva Stimulating Tablets

Dry mouth or clinically known as xerostomia is a symptom of decrease in saliva flow due to salivary glands dysfunction. Patients with a persistently dry mouth may develop problems associated with poor oral hygiene,increased dental carries,oral infections, burning sensations,problem in speaking and difficulty in swallowing.Saliva stimulating tablets are one of the current therapies for management of xerostomia.Currently,saliva stimulating tablets that are available in the market are imported and not being manufactured locally.Thus, development of saliva stimulating tablets to fulfill the local demands is needed. Its development will contribute significantly to the patients,local pharmaceutical industry and also the country especially from the economic aspect. The invened products have wider indications and much more cheaper as compared to an existing product.In additional, the newly invented products also shown better hardness properties which suited its characteristics as a chewable tablet.Furthermore,the pH of the invented products which is less acidic will reduce the occurrence of teeth enamel erosion as compared to the marketed product. The addition of calcium salts in the formulations of the invented products will further protect the teeth enamel from erosion

Kuala Lumpur Kuala Lumpur

ID : tm2933310304


New Pharmaceutical Material in Direct Compression Tablets

Manufacturing of tablets by direct compression is now gaining popularity as compared to other existing method.The method offer many advantages such as simple processing,reduce time and cost of productions. In this invention we found that a polysaccharide group which is abundantly available locally has shown greatly potential as a new pharmaceutical material in direct compression tablets,which are appeared to be better flowability and having good holding capacity after being physically modified.

Kuala Lumpur Kuala Lumpur

ID : tm2933510306


New Generation of Dental Posts for Rehabilitation of Endodontically Treated Tooth

Commercially, two homogonous-types of dental posts, namely cast metal and prefabricated posts, are usually employed in order to rehabilitate the root canal and provde retention for crown. However, there are significant mismatch between thermo-mechanical material properties of these dental posts and surroundings. This results in the extreme localized stress and root fracture. In order to overcome the problem of the currently available dental posts, the concept of Functionally Graded Materials (FGMs) can be applied. In FGMs composition and properties varies continuously in preferred direction(s). Therefore, fabrication of dental posts with multilayered structure which matches the mechanical properties of dentine at both coronal and apical parts is most desirable.

Kuala Lumpur Kuala Lumpur

ID : tm2933610307


New Generation Of Dental Post: Based On The Concept Of Functionally Graded Materials.

he fracture of tooth, generally, occurs either at the coronal or apical region after restoration using available dental posts in the market. New formulation and deign of biocompatible dental materials such as 3 showed better performance. The graded structure design of the dental post based on Ti-HA-Zro2-Al2O can combine diverse properties into a single material system. The dental post exhibited a high stiffness in the coronal region which gradually reduced to the value of dentine at the apical end. The multilayered functionality graded post dissipated the stress from the crown to the dentine, considerably. Therefore, the gradual change in microstucture eliminated stress concentration and reduced the probability of interfacial server shear stress. The new innovation in the fabrication of multilayered structured dental posts will definitely enhance the clinical durability of endodontically treated tooth and thus uplifting the patients quality of life.

Kuala Lumpur Kuala Lumpur

ID : tm2933710308


New Generation Of Dental Post Based On The Concept Of Functionally Graded Materials

Fabricated multilayer dental post with a functionally graded design is a novel product that exhibits graded properties varied from coronal to apical parts of the tooth. The new dental post definitely performs better than posts available in the market and improves the quality of human life.

Kuala Lumpur Kuala Lumpur

ID : tm2933910310


MyCoKill Cream

Details on the invention :
? MyCoKill is active against fungi that cause wound infection and is most active against dermatophytes
? Active ingredient is a water extract of Acalypha siamensis
? The effectiveness is determined by testing its antifungal activity in different concentration of Mycokill cream preparation
? New and alternative antiseptic cream

Kuala Lumpur Kuala Lumpur

ID : tm2934410315


Mouth Wash Oral Care

Antimicrobial, antioxidant,anti-inflammatory and ant-iulcer activities of ethanol extracts from Cinnamomun cassia were evaluated. Antioxidant: 1.0mg/mL, ethanol extracts of C.cassia (96.30%) exhibited greater inhibition than-tocopherol(93.74%) on FeCl2-ascorbic acid induced lipid peroxidation of rat liver homogenate in vitro. C.cassia demonstrated highest superoxide anions scavenging activity and strongest anti-superoxide formation activity. Antibacterial: In vitro antibacterial activities of ethanol extracts from Cinnamomun cassia were investigated by agar-well diffusion method against 5 strains of bacteria of oral cavity. Results from antibacterial tests demonstrated that Cinnamomun cassia had excellent inhibitory effect against all bacteria of oral cavity. Minimum inhibitory concentrations of extract were 500g/ml against bacterial all bacterial strains.In vitro anti-inflammatory activity: Total ethanol extract of Cinnamomun cassia (100microg/ml) significantly blocked production of interleukin (lL)-1 beta, lL-6 and tumor necrosis factor (TNF)-alpha from RAW264.7 cells stimulated by lipopolysaccharide (LPS) up to 20-70%. In vitro anti-inflammatory and anti-ulcer activity which can be used as mouth wash.

Kuala Lumpur Kuala Lumpur

ID : tm2935410325


MFPintar (SmartMF)

Sebuah mesin analisis impedans berbilang
(MFBIA) untuk memantau komposisi badan
pengguna dan pengurusan penyakit. Sistem
yang dibangunkan terdiri daripada perkakasan
dan modul perisian
Sumber Dana Geran Penyelidikan

Kuala Lumpur Kuala Lumpur

ID : tm2936010331


Melasta Tablet for Anti Hypertension

Traditionally the leaves and shoots of Melastoma Malabathricum have been widely used for the treatment of wounds, post-natal care, prevention of scars from smallpox infection, stomach ulcers, dysentry, diarrhea & hypertension.

? Chinese in northern region of Peninsular Malaysia used the aqueous extract for lowering their blood pressure and the Malay used stem bark as brushes to clean teeth whilst the aqueous root extract is used to relieve toothache
? Experimental results found the polar fraction like the ethanol & methanol extract, and pure compounds (ie, ruthin & quercetin) possessed the activities as anti-inflammatory, wound healing and lowering the blood pressure and heart rate. While the less polar fraction like hexane and chloroform extracts possessed antinociceptive effect

Thus, MELASTA tablets are extracted from the leaves of Melastoma Malabathricum, each 400mg tablet contain polar and non polar compounds should be taken 2 tablets per day 30 minute before breakfast is anti-hypertension, anti-ulser, wound healing, anti-inflammation and analgesics.

Kuala Lumpur Kuala Lumpur

ID : tm2936110332


Medical Identifier For The Pilgrims During The Hajj Season

Without papers that showing their location as well as contact number, yet with the problems of communication (languages barriers), always puts a tremendous pressure on the security officers who taking care of pilgrims. Because of that, we intended to design and develop a medical identifier, which mainly used for pilgrims due to control the problems mentioned earlier. In this research, we focused on designing a new product device using bracelet that equipped with additional function of technology, which capable to monitor the pilgrims health condition, as well as pilgrims data information. This proposed device invented was capable to assist the pilgrims and Hajj staff in managing and controlling pilgrims during Hajj season. This device will be instaleed in this new design of bracelet, and replaced the existing bracelet, which normally used and worn by pilgrims, nowadays. Furthermore, the existing bracelets are only capable to show the tag of pilgrims information, such as name, country of origin, identification no etc.

Kuala Lumpur Kuala Lumpur

ID : tm2936310334


Medical Communication Center

This system integrated several live videos and images from the endoscope, microscope, etc. In normal operation room all equipment are scattered around the surgeon and he/she must continuously change his/her position to find the relevant video or image. In this system, a big touch screen monitor to bring all videos in one screen in used. Surgeons can easily manipulate the videos, such as, maximizing, zooming-in and zooming-out. They only switch between videos via voice command. It is equipped with a voice detection tools to facilitate calling the videos. With this feature, surgeons no longer need to touch the monitor.

Kuala Lumpur Kuala Lumpur

ID : tm2936410335


MEDCOM-OR Integrated Operating Theatre Management System

Products related to integrated operating room management system.

Produk berkaitan pengurusan sistem bilik bedah secara bersepadu.

Kuala Lumpur Kuala Lumpur

ID : tm2937210343


Laryngotracheal Dissection Box (Prototype II): An Improved Version of Multifunction Tool and Simulator Designed for CO2-Laser &Endoscopic Endolaryngeal Surgery Training

Workshop and hands-on dissection are very important training methodology for postgraduate students and otolaryngology trainees.Instead of making unnecessary mistakes and preventing complications during live surgery to patient,a safer and practical alternative is by practicing on preserved excised specimens.This allows proper techniques of surgery of procedures to be taught and demonstrated after which the participant can practice until they feel comfortable and satisfied with the results.In additional,the image can be projected for display to allow step-by step demonstration.Laryngotracheal dissection box is a practical all in one solution tool for the purpose of training and simulation involving excised specimens of larynx and trachea-bronchial tree.It consists of cubical-shaped box,series of inlet and outlet ports, and internal mounting stands to hold the specimen being used. The commonly used specimens derived from beef,goat and rabbit.Its designallows experimental work using both endolaryngeal instruments as well as laser especially carbon dioxide.LASER is an acronym for Light Amplification of Stimulated Emission of Radiation. We strongly recommend this Laryngotracheal Dissection Box (Prototypa II) innovation as benchmarking training tool and we look forward for its commercialization potentials.

Kuala Lumpur Kuala Lumpur

ID : tm2937710348


Intervertebral Distractor

Details on invention:
? A device discloses a medical apparatus comprises a pair of splints, an adjustable connecting means and a fastening means.
? Provide proper placement for cage or bone graft while distracting the invertebral space
? Avoid residue kyphosis
? Reduce the gap after the cage or bone graft insertion

Kuala Lumpur Kuala Lumpur

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